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</pre>We are pleased to announce DOTcvpSB, a Matlab toolbox<br>
for dynamic optimization of nonlinear dynamic systems,<br>
focused on applications in systems biology.<br><br>
Software and documentation are available at:<br>
<a href="http://www.iim.csic.es/~dotcvpsb/" eudora="autourl">
http://www.iim.csic.es/~dotcvpsb/<br><br>
</a>DOTcvpSB facilitates the statement and solution of<br>
dyamic optimization (optimal control) problems related<br>
with biological systems, modelled with ODEs (although<br>
arbitrary black-box models can be handled as well).<br>
The toolbox can import SBML models for the dynamics via<br>
the SBMLtoolbox.<br><br>
Examples of problems provided with the toolbox:<br>
- optimal drug infusion to a patient <br>
- minimization of intracellular oscillations<br>
- bioreactor optimization<br><br>
DOTcvpSB is described in the following paper:<br><br>
Hirmajer, T., E. Balsa-Canto and J. R. Banga (2009)<br>
DOTcvpSB, a software toolbox for dynamic optimization <br>
in systems biology. BMC Bioinformatics 2009, 10:199.<br>
<a href="http://www.biomedcentral.com/1471-2105/10/199/abstract/" eudora="autourl">
http://www.biomedcentral.com/1471-2105/10/199/abstract/<br><br>
<br>
</a>More details, documentation and examples available at:<br>
<a href="http://www.iim.csic.es/~dotcvpsb/" eudora="autourl">
http://www.iim.csic.es/~dotcvpsb/<br><br>
</a>Regards,<br><br>
Julio R. Banga ( julio@iim.csic.es )<br><br>
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